GENOMIC STRUCTURE, EVOLUTIONARY ORIGINS, AND REPRODUCTIVE FUNCTION OF A LARGE AMPLIFIED INTRINSICALLY DISORDERED PROTEIN-CODING GENE ON THE X CHROMOSOME (LAIDX) IN MICE

Mouse sex chromosomes are enriched for co-amplified gene families, present in tens to hundreds of copies.Co-amplification of Slx/Slxl1 on the X chromosome and Sly on the Y chromosome are involved in dose-dependent meiotic drive, however the role of other co-amplified genes remains poorly understood.Here we demonstrate that the co-amplified gene fam

BACKGROUND: Metastatic melanoma has shown only limited responsiveness to chemotherapy or immunotherapy.The most commonly used single-agent chemotherapy comes from the nitrosourea group of agents and provides response rates of less than 20%.Several cytotoxic agents have been combined with no dramatic benefit.The incorporation of tamoxifen or interfe

Calcium signals drive an endless array of cellular responses including secretion, contraction, transcription, cell division, and growth.The ubiquitously expressed Orai family of plasma membrane (PM) ion channels mediate Ca2+ entry signals triggered by the Ca2+ sensor Stromal Interaction Molecule (STIM) proteins of the endoplasmic reticulum (ER).The

Classical DC-DC converters used in high voltage direct current (HVDC) power transmission systems, lack in terms citroen c4 grand picasso boot liner of efficiency, reduced transfer gain and increased cost with sensor (voltage/current) numbers.Besides, the internal self-parasitic behavior of the power components reduces the output voltage and efficie

cmpk bolus The quality of sports facilities, especially football pitches, has gained significant attention due to the growing importance of sports globally.This study examines the effect of two different cutting systems, a traditional ride-on mower and an autonomous mower, on the quality and functional parameters of a municipal football field.The a